Abstract: The theoretical logic of "co-opetition", which advocates cooperation in competition and competition in cooperation, has strong theoretical explanatory power and practice-guiding significance for the development of higher education clusters in the Guangdong-Hong Kong-Macao Greater Bay Area. According to the theory of "co-opetition" and the analysis of the actual needs for the development of competition and cooperation of higher education in the Guangdong-Hong Kong-Macao Greater Bay Area, the "co-opetition" in the clusters of higher education in the Guangdong-Hong Kong-Macao Greater Bay Area can be divided into two types: 1) homogeneous competition and cooperation, which had better follow the practical logic of long-term competition and short-term cooperation; 2) heterogeneous competition and cooperation, which had better follow the practical logic of long-term cooperation and short-term competition.